One of the molecular mechanisms of the pH elevation is that: 1) the carboxyl group (R-COO-) but not H+ composing weak organic acids in foods is absorbed into the body, and 2) the absorbed the carboxyl group (R-COO-) behaves as a pH buffer material, elevating the interstitial fluid pH. 2018 Oct 19;19(10):3244. doi: 10.3390/ijms19103244. The Regional factors, periodic clinic visits, and waist circumference before the quake were identified as predictive factors on multivariate analysis for the deterioration of HbA1c. Obesity, in particular Dysmotility symptoms were found in 32.6% and acid reflux symptoms in 20.5%. Methods: Of the 323 participants, 309 completed the weight-loss program and were included in the analyses. Results: These metabolic abnormalities are all risk factors for cardiovascular disease (CVD), and the epidemiological association strategies. Diabetes Care 2002, 25:1252–1253. Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine. Després JP, Lemieux I, Bergeron J, Pibarot P, Mathieu P, Larose E, Rodés-Cabau J, Bertrand OF, Poirier P. Arterioscler Thromb Vasc Biol. Patients with MetS (n = 60, 362 ± 53 CARR U) showed a significantly higher oxidant capacity by d-ROMs than those without MetS (n = 120, 324 ± 55 CARR U, P < 0.01). Recent studies have helped clarify the mechanisms underlying the vascular dysfunction that leads to cardiovascular outcomes in diabetes. Multiple logistic analysis showed that female gender was significantly associated with dysmotility symptoms compared with controls. It mediates its insulin-sensitizing and anti-atherogenic effects on target tissues via 2 receptors—adiponectin receptors 1 and 2 (ADIPOR1 and ADIPOR2). Metabolic syndrome (MetS) consists of a clustering of cardiovascular risk factors, and individuals with this condition have an elevated risk of developing cardiovascular diseases and type 2 diabetes. The Japanese criteria for MetS were used to evaluate the prevalence of MetS and pre-MetS in this study [23, The clinical importance of the metabolic syndrome is that this group of risk factors greatly increases the likelihood of cardiovascular events, the major source of disease morbidity and mortality in patients with obesity and type 2 diabetes. The earliest definition, which included risk factors such as insulin resistance, hyperglycemia, hypertension, and cholesterol, has undergone many transformations. One of the methods to evaluate oxidative stress in clinical medical settings is the reactive oxygen metabolites (d-ROMs) test. Tumor budding is prognostically important in ICC, and its pathogenetic role in biliary tract carcinomas might be different by anatomic location. From the University of Tokyo Hospital pathology archives, we reviewed 107 cases of ICC, 54 cases of perihilar cholangiocarcinoma, and 40 cases of extrahepatic cholangiocarcinoma (ECC); we also investigated the significance of tumor budding in ICC, in comparison with perihilar cholangiocarcinoma and ECC. 10.3132/dvdr.2007.062. To clarify the best combination of MetS components to predict future cardiovascular disease (CVD) events, we estimated CVD risk in Japanese patients with type 2 diabetes according to MetS components. studied the cut‐off point of waist circumference (WC) for the clustering of two or more metabolic risk factors among the three non‐WC components of Japanese metabolic syndrome (JMetS) and proposed to amend JMetS regarding the cut‐off point of WC for women 1.However, the most dangerous drawback of JMetS criteria is that it makes abdominal obesity … Osteoporosis is preventable if doctors want it to be, and every doctor can contribute. Among 778 subjects, 395 persons were included in the final analyses. It is up-beat and optimistic, with a touch of humor; it is scientifically based but provides easy-to-follow guidelines for lifelong maintenance of skeletal structure and function. In contrast, several dietary foods have direct and indirect benefits in maintaining the interstitial fluid pH to the normal range by improving buffering capacities, suppressing proton production, and activating proton transporters, which strengthen the effect of appropriate diet on metabolic health. Patients were categorized according to the presence three MetS components in addition to hyperglycemia. Therefore, pH reduction in the interstitial fluid may cause the onset of metabolic dysfunction. Childhood obesity has become major health concern for physicians, parents, and health agencies around the world. The corresponding odds ratios for men and women were 2.27 (P < 0.01) and 1.95 (not significant), respectively. Clipboard, Search History, and several other advanced features are temporarily unavailable. Dysmotility and acid reflux symptom were diagnosed by using FSSG. However, the consultation and follow-up rates for the intervention are still low. In Asians, decreasing waist circumference increased the crude prevalence of the metabolic syndrome from 12.2 to 17.9%. resistance and dyslipidemia have been proposed. In an apparent attempt to maintain glucose homeostasis, the compensatory response to a decrease in insulin-stimulated glucose up take is an increase in plasma insulin concentration. 2005, 94: 188-203. in Japanese 24. PMID: 11712931; ppublish. Metabolic syndrome was defined using the criteria recommended in the NCEP ATP III guidelines and modified NCEP criteria. Zurück zum Zitat Fujita T: The metabolic syndrome in Japan. 2001 Nov 21;286(19):2400-1; author reply 2401-2.  |  The clinical role for seasonal variations in metabolic risk factors remains to be further elucidated. These findings suggest that the presence of metabolic syndrome could have a significant impact on the early recovery of urinary continence after robot-assisted radical prostatectomy. In 2008, the Japanese government started a new screening and educational system for metabolic syndrome, focusing on visceral fat accumulation [ 40 ]. PubMed CrossRef Google Scholar. alone. Subjects met both criteria were considered as overlap group. Emerging evidence suggest that increased visceral adipose tissue stimulates You can request the full-text of this article directly from the authors on ResearchGate. dysfunction is correlated with visceral adiposity, insulin resistance and alterations in the levels of a variety of circulating factors. With a lower waist circumference cutoff, the prevalence of the metabolic syndrome is comparable to that in Western populations. To investigate the prevalence of the metabolic syndrome in Japan, we analyzed cross-sectional data from 3574 middle aged Japanese (2947 men and 627 women, aged 40-59 years) in a large company, whose visceral fat accumulation was assessed by computed tomography. Comparisons between anthropometric indices for predicting the metabolic syndrome in Japanese. The aim of the present study was to compare the postprandial response of various metabolic parameters, blood pressure, adiponectin, and oxidative stress to 75-g oral glucose tolerance test (OGTT) in men with (n = 23) and without (n = 7) abdominal obesity based on waist circumference (WC) cutoff value of 85 cm (based on the Japanese criteria for the metabolic syndrome). Seasonal Variation in Metabolic Syndrome Components: How Much Do They Influence the Diagnosis of Metabolic Syndrome? Hypertension Research, official publication of the Japanese Society of Hypertension, publishes papers reporting original clinical and experimental research in the field of hypertension and related cardiovascular diseases. To establish a unified working diagnostic tool for the metabolic syndrome (MetS) that is convenient to use in clinical practice and that can be used world-wide so that data from different countries can be compared. Postprandial metabolic dysregulation plays a role in the development of atherosclerosis. Sedentary time was also associated with the risk of MetS (Ptrend = 0.018). Zurück zum Zitat Lee JS, Kawakubo K, Mori K, Akabayashi A: Effective cut-off values of waist circumference to detect the clustering of cardiovascular risk factors of metabolic syndrome in Japanese men and women. Although its prevalence is extremely high among diabetic patients, its prevalence in those with no history of CVD has not been determined. The IDF has produced a new set of criteria for use both epidemiologically and in clinical practice world-wide with the aim of identifying people with the MetS to clarify the nature of the syndrome and to focus therapeutic strategies to reduce the long-term risk of cardiovascular disease. Nat Clin Pract Cardiovasc. A total of 116 (38.4%) and 203 (67.2%) of the 302 patients were continent at 1 and 3 months after robot-assisted radical prostatectomy, respectively. Conclusions. In the Japanese definition, central obesity must be presented. Ota T, Takamura T, Hirai N, Kobayashi K: Preobesity in World Health Organization classification involves the metabolic syndrome in Japanese. PMID: 11712929; CIN: JAMA. The proportion of subjects having metabolic syndrome was 25.3%. In male patients, although both definitions of MetS were significant predictors for CVD, individual components of MetS, such as hyperlipidemia or hypertension, were equivalent or better predictors. The criteria used to define this syndrome identify a larger phenotype which is related to a higher risk of developing cardiovascular and metabolic diseases than the simple addition of risks associated with each criterion. Implications for Improved Definition. Int J Mol Sci. While metabolic syndrome (MetS) is considered an oxidative condition, the oxidative status in MetS has not been fully examined using this test. 2012 Feb;33(2):189-93. doi: 10.1038/aps.2011.204. Tsubokura M, Takita M, Matsumura T, Hara K, Tanimoto T, Kobayashi K, Hamaki T, Oiso G, Kami M, Okawada T, Tachiya H. BMC Public Health. The results suggest that the current MetS criteria should be modified when applied to patients with type 2 diabetes. FSSG {frequency scale for the symptoms of gastroesophageal reflux disease (GERD)} was developed as a diagnostic tool for dysmotility and acid reflux symptoms. KeywordsObesity–Insulin resistance–Type 2 diabetes–Visceral obesity–Dyslipidemia–Cardiovascular disease–Hypertension–Proinflammatory state–Diagnosis–Epidemiology. Along with the body weight reductions, significant improvements were observed in most of MetS components within the DI and II groups. We also determined the optimal cutoff value for physical activity required to decrease the risk of developing MetS. Results: Japanese obese children were found to have a significantly lower prevalence (17.7%) of the metabolic syndrome than U.S. obese adolescents (28.7%, p = 0.0014). In the 6-year follow-up study, cardiac disease occurred in 11.7% of the subjects in the metabolic syndrome group and in 6.7% of the subjects in the non-metabolic syndrome group. The odds ratios (OR) for MetS in the highest and middle tertiles of light-intensity lifestyle activity were 0.44 [95% confidence interval (CI): 0.24 to 0.81] and 0.51 (95% CI: 0.29 to 0.89) relative to the lowest tertile, after adjustment for age, sex, smoking, calorie intake, accelerometer wear time and MVPA (Ptrend = 0.012). Importantly, obesity accelerates atherosclerosis progression already in children and young adults. The participants’ enrol- ment for the present study is presented in the Figure. Smoking was an independent risk factor for overlap among two symptoms. Presenting with the metabolic syndrome is likely to raise awareness in the physicians to screen for these chronic diseases that are often clinically silent for a long time. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. 2001 Nov 21;286(19):2401-2. All rights reserved. A total of 179 men and 304 women, aged between 30 and 64 years, participated in this study. Inevitably, this widening of the threshold will capture more patients at risk of cardiovascular events. Disturbances in the functioning of the transporters cause abnormal intracellular fluid pH of the cells and dysfunction of metabolic homeostasis, leading to the development of metabolic diseases and a decrease in physical fitness level. Participants were divided into two groups using the Japanese criteria for MetS as those with MetS or pre-MetS, and those without MetS. The association between physical activity and MetS was analyzed using logistic regression with the following covariates: sex, age, sedentary time, low intensity activity, calorie intake, smoking, menopause and body mass index. 18. WHO: Obesity: preventing and managing the global epidemic: report on a WHO consultation on Obesity, Geneva, 3–5 June, 1997. A total of 104 men (abdominal circumference > or = 85 cm; age, 52.1 + or - 9.3 years) were assigned to one of three groups: no intervention (NI, n = 34), direct intervention (DI, n = 34) or indirect intervention (II, n = 36), the last of which consisted of subjects who did not participate in the direct LSI but whose wives did. When analyzing the spouse pairs in group II, significant correlations were observed in weight loss (r = 0.57) and decreased total energy intake (r = 0.54) between wives and husbands. A triaxial accelerometer was used to measure light-intensity lifestyle activity [1.6–2.9 metabolic equivalents (METs)] and sedentary time (≤1.5 METs). 10 Metabolic syndrome has been associated with increased risk for diabetes mellitus and cardiovascular disease, as well as … Osteoporosis is a global threat because it can impact every human being as they age. Acta Pharmacol Sin. In this brief review, we will cover several key concepts in the pathophysiology of type 2 diabetes that confer increased cardiovascular risk and influence the choice of oral therapies for this widespread disorder. Conclusions In 2008, Japan introduced a metabolic syndrome screening and intervention program specifically targeting individuals aged 40 to 74 years of age. The metabolic syndrome - an ongoing story. The percentage thiobarbituric acid-reacting substances tended to be lower in the WC less than 85 group (vs baseline: P = .07), but not in the WC at least 85 group, albeit statistically insignificant (WC <85 vs >/=85 group: P = .057). Further studies are required to establish the clinical applications of this test to MetS practice and clarify the biological mechanisms of the observed relationships. A Consensus Statement from the International Diabetes Federation, Renal Dysfunction Induced by Kidney-Specific Gene Deletion of Hsd11b2 as a Primary Cause of Salt-Dependent Hypertension, Genome-wide analysis of murine renal distal convoluted tubular cells for the target genes of mineralocorticoid receptor, A novel compound heterozygous mutation of Gitelman's syndrome in Japan, as diagnosed by an extraordinary response of the fractional excretion rate of chloride in the trichlormethiazide loading test, Cardiovascular risk in the spectrum of type 2 diabetes mellitus. This study aimed to determine the association between objectively measured physical activity and MetS in middle-aged Japanese individuals. Miyatake N, Matsumoto S, Fujii M, Numata T. Diabetes Res Clin Pract. The effects of the relationship between eating behavior and nutritional intake on MetS remained unclear. Qualitative content analysis was used to analyze the data, and four themes were extracted: Self-taught practices, Defiance, Hesitation, and Resignation. Tumor budding in ICC was associated with many pathologic indicators associated with invasion, such as major vascular invasion (P=0.012) and Union for International Cancer Control stage (P=0.007). The consensus statement emerged following detailed discussions at the IDF workshop. The subjects who had 3 or more risk factors were judged as having metabolic syndrome. Recent research has indicated Recent research has indicated Long working hours and metabolic syndrome among Japanese men: a cross-sectional study | springermedizin.de Changes in metabolic profiles after the Great East Japan Earthquake: a retrospective observational study. Conclusions— The metabolic syndrome is a major determinant of ischemic cardiovascular disease among middle-aged Japanese men and women, in particular among smokers. with an increased risk of several malignancies. However, the new findings indicate that seasonal variation should be considered in diagnosis and management decisions. We also evaluated the factors that determined the association between the prevalence of MetS and pre-MetS and the physical activity cutoff value using classification and regression tree (CART) analysis. We hypothesized that the evacuees would experience deteriorated metabolic status based on previous reports of natural disasters. When TCA cycle functions under an aerobic condition, most of the final product of glycolysis is CO 2 . Indirect LSI in abdominally obese men whose wives were undergoing LSI led to loss of weight and a decreased incidence of MetS, suggesting that indirect LSI may be an effective program for eliciting beneficial change in health status. A cross-sectional survey was performed in Japanese underwent the routine medical examination. would facilitate both clinical diagnosis and future research to accurately assess risk and to identify preventative and therapeutic Our results also suggest that moderate physical activity of > 26.5 METs h/week may decrease the risk of developing MetS and pre-MetS in middle-aged Japanese individuals. Two revisions have focused on visceral adiposity as an essential component of the syndrome, particularly in Asian populations. Not in conformity with the NCEP-ATP Ill, however, a cut-off value of 85 cm was used for waist girth as an indicator of abdominal obesity. The cause of the syndrome is not yet clear, but insulin Analysis from the Japan Diabetes Complications Study, The metabolic syndrome—A new worldwide definition, Metabolic Syndrome - Definition and Diagnostic Criteria in Japan, Prevalence of Metabolic Syndrome in Okayama Prefecture, Japan, Metabolic syndrome-a new world-wide definition. Useful predictors for the patients' prognosis after surgery have not been fully established. The IDF has also produced recommendations for additional criteria that should be included when studying the MetS for research purposes. Overlap between dysmotility and acid reflux symptoms was common in Japan. Our results suggest that the public health advisors recognize the importance of modification of clients' health-related misperception, improve their skills to develop a positive rapport with clients, and be involved in creating a supportive environment conducive to a healthy lifestyle. 2005, 94: 188-203. in Japanese The Examination Committee of Criteria for 'Metabolic Syndrome' in Japan: Criteria for 'metabolic syndrome' in Japan. Although the IDF acknowledged specific cut-offs 25 for different genders and ethnicities (Alberti et al., 2005), the Japanese movement towards country-specific diagnostic criteria for MS is controversial (Banerjee and Misra, 2007; ... 11 Although the prevalence of MetS varies from 10 to 84% depending on the sex, age, race and ethnicity, 40% of the population in the USA and nearly 30% in Europe have MetS and, in Japan as well, the prevalence of MetS in Japanese residents has steadily increased, reaching 10-20%. In the present study, we examined the association between a single nucleotide polymorphism (SNP) in the 5´ flanking region of the ADIPOR1 gene and body mass index (BMI) in the Japanese population.Methods: Association of an SNP (rs4989513) with the BMI was examined in 774 postmenopausal Japanese women.Results: Rs4989513 SNP was significantly associated with the BMI (P = 0.0412).Conclusion: Genetic variation at the ADIPOR1 gene locus is associated with BMI, suggesting that the ADIPOR1 gene is involved in the development of obesity. The factors to alleviate MS components were explored using classification and regression tree (CART) analyses. Background and Purpose— The current criteria of metabolic syndrome (MetS) are not based on evidence derived from prospective studies on cardiovascular disease (CVD). Our studies indicate that lowered interstitial fluid pH occurs in diabetes mellitus, causing insulin resistance via reduction of the binding affinity of insulin to its receptor. The CART analyses revealed that a weight reduction of 8.1% in baseline body weight was sufficient to improve at least 1 component of MS. Finally, the IDF has identified areas where more studies are currently needed; these include research into the aetiology of the syndrome.  |  In this new edition, the authors point out the enormous scale of the problem in terms of human suffering, morbidity and mortality on the one hand, and the astronomical national costs on the other. Childhood obesity: a life-long health risk. Ethnic differences are likely to exist between populations across Asia. In this study, postoperative urinary continence was defined as no leak or the use of a security pad. A health screening program was held for the evacuees in Soma in September 2011. Aims. Results. The baseline characteristics and incidence/hazard ratio of cardiovascular events (coronary heart disease and stroke) were determined in 1,424 Japanese type 2 diabetic patients with and without MetS, as defined by WHO (WHO-MetS) or the NCEP. It is well known that body weight loss through a direct (supervised) lifestyle intervention (LSI) improves obesity-related metabolic disorders. To encourage its use, efforts have been made to unify its definition, with the aim of implementing a comprehensive care approach to address the needs of people with the metabolic syndrome. These results suggest that moderate weight loss of 8%-13% contributes to improving the MS components in overweight Japanese women. metabolic syndrome in Japan is necessary to reduce the risk of cardiovascular disease. There were participants from each of the five continents as well as from the World Health Organization (WHO) and the National Cholesterol Education Program-Third Adult Treatment Panel (ATP III). National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. A multivariate regression model was used to determine pre-quake predictive factors for elevation of hemoglobin A1c (HbA1c) in the tsunami group. The first systematic review of cardiovascular risk factors, with insulin resistance as a common denominator, was published in 1988 by G. Reaven under the title of “Syndrome X”. The results of this cross-sectional study indicate that the Exercise and Physical Activity Reference for Health Promotion 2006 is inversely associated with the prevalence of MetS in men. Bone is every doctor's and every body's business. Methods Metabolic Syndrome and Cardiac Disease in Japanese Men: Applicability of the Concept of Metabolic Syndrome Defined by the National Cholesterol Education Program-Adult Treatment Panel III to Japanese Men-The Tanno and Sobetsu Study, The New Worldwide Definition of Metabolic Syndrome Is Not a Better Diagnostic Predictor of Cardiovascular Disease in Japanese Diabetic Patients Than the Existing Definitions: Additional analysis from the Japan Diabetes Complications Study, Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement, Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III), Role of Insulin Resistance in Human Disease, Is the Diagnosis of Metabolic Syndrome Useful for Predicting Cardiovascular Disease in Asian Diabetic Patients? In addition, emerging evidence suggests that lowering the threshold of waist circumference in Asian populations increases the prevalence of the metabolic syndrome. USA.gov. J Jpn Soc Int Med. Social jetlag, ie, the mismatch between biological and social timing, has been suggested to induce obesity and cardiometabolic abnormalities. On multivariate logistic regression analysis, metabolic syndrome and the duration of hospitalization were significantly correlated with the 1-month continence status. Univariate and multivariate Cox regression analyses revealed tumor budding as a powerful prognostic factor for both recurrence-free survival (RFS) and overall survival (OS) in ICC by univariate (RFS: hazard ratio [HR]: 2.666; 95% confidence interval [CI]: 1.517-4.683, OS: HR: 4.206; 95% CI: 2.447-7.230) and by multivariate analyses (RFS: HR: 3.038; 95% CI: 1.591-5.973, OS: HR: 4.547, 95% CI: 2.348-8.805). Metabolic syndrome is one of the most serious public health concerns globally, including developing countries [ 1 ]. Methods— In a 14-year follow-up study of 2452 community-dwelling Japanese individuals aged ≥40 years, we examined which of the MetS criteria are most predictive for the development of CVD. Recent studies have reported that ADIPOR1 deficiency in mice results in increased body weight and obesity. The Japanese national guidelines have also suggested that abnormalities in adipose tissue metabolism are an underlying molecular cause of the syndrome. In Japan, MS is acknowledged as a major public health concern that has been addressed by developing country-specific diagnostic criteria and guidelines (. The participants were enrolled in a 3-month weight-loss program with a low-calorie diet with or without exercise. The present study included a total of 302 consecutive Japanese patients with clinically localized prostate cancer who underwent robot-assisted radical prostatectomy. hypertension, dyslipidemia and excess waist circumference (WC) (according to either Japanese or Asian cut-off values). The serum oxidant capacity (measured by the d-ROMs test) was cross-sectionally determined in cardiovascular disease-free and non-smoking women who were not taking medications (n = 180; mean age, 60 ± 10 (standard deviation) years). Reducing waist circumference by at least 3 cm is recommended for improving metabolic syndrome in obese Japanese men. Epub 2008 Mar 20. The metabolic The results of our study suggest that public health messages and guidelines should be refined to include increases in light-intensity lifestyle activity and/or decreases in sedentary time, alongside promoting MVPA, to prevent MetS. Obesity and metabolic syndrome (MS) are strongly associated with erosive esophagitis (EE). To evaluate the impact of metabolic syndrome on the early recovery of urinary continence after robot-assisted radical prostatectomy. We conducted a group interview targeting public health nurses and qualified dieticians of "A" prefectural branch office of the Japan Health Insurance Association who were regularly involved in performing the intervention. Fujii M, Numata T. diabetes Res Clin Pract as hemoglobin ( Hb ) and (... Considered in diagnosis and management decisions into the aetiology of the metabolic was! Sentences containing `` metabolic syndrome is a major determinant of ischemic cardiovascular disease M, Numata T. Res. Parameters May be important in preventing atherosclerotic diseases evaluate oxidative stress in clinical settings! Are temporarily unavailable reduction in the Japanese National guidelines have also suggested that abnormalities in adipose tissue have been.... Human being as they age 1 ] threat because it can impact every human being as they age for in... 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